Coming from Cologne:

Motorway crossing "Köln-Süd" onto the A555 direction of Bonn. Exit "Köln Godorf/Wesseling Nord" behind the bridge. At the second red light turn right on "Industriestrasse" direction of Wesseling. At the second red light turn left up to "Brühler Strasse". Turn right up to sign post reading "Hotel am Rhein".

 
Coming from motorway A61:

Motorway crossing "Bliesheim" onto the A553 direction of Köln. Exit "Brühl-Ost". At the red light turn right on "Brühler Strasse" up to Wesseling. There you turn into "Kölner Strasse" and look for sign post "Hotel am Rhein".

By tram from Cologne Main Station:

From cologne central station you have to take the tram line 16 direction "Bonn-Bad Godesberg". Leave the train at the station Wesseling Mitte. From the station Wesseling you reach the hotel by 10 minutes walking: please turn right into the pedestrian zone and follow Bahnhofstrasse. At the end of the street please turn to the left into Kölner Strasse. After 250m you reach the Hotel am Rhein.